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Influence of post-LASIK corneal healing on scanning laser polarimetric measurement of the retinal nerve fibre layer thickness

¹ 1st Department of Ophthalmology, Semmelweis University, Budapest, Hungary
² Biometry Unit

Correspondence to:
Correspondence to:
Gábor Holló, MD, PhD, 1st Department of Ophthalmology, Semmelweis University, H-1083, Budapest, Tömö u 25–29, Hungary;
hg{at}szem1.sote.hu

ABSTRACT
Aim: To investigate the influence of laser assisted in situ keratomileusis (LASIK) on the values for retinal nerve fibre layer thickness (RNFLT) as measured with scanning laser polarimetry (SLP) during the healing process of the cornea after LASIK.

Methods: SLP with the GDx instrument was performed on 20 consecutive healthy subjects without any eye disease undergoing LASIK for ametropia correction. The SLP measurements were performed before the surgery, and at 1 and 3 days, as well as at 3 months, after LASIK. Thickness data from images of one randomly selected eye per subject were analysed using the ANOVA and Duncan multiple comparison tests. Correlation coefficients between RNFLT data and the treatment parameters were also calculated.

Results: Somewhat similar results were found for the different retinal areas. The measured values for superior average RNFLT decreased significantly at all time points compared to the preoperative baseline (p<0.003, Duncan test), but increased significantly between postoperative day 1 and the final visit at 3 months (p=0.025, Duncan test). Inferior average RNFLT in the early postoperative days was significantly smaller than at 3 months after LASIK (p<0.05, Duncan test), and tended to be smaller than at baseline. The thickness values before surgery and at the final visit, however, showed no significant difference (p=0.698, Duncan test) in this region. Ellipse average RNFLT was significantly smaller in the early postoperative days than the baseline value before LASIK. However, the measured value had significantly increased again by the time of the final visit (p<0.02, Duncan test). This value at the final visit showed no difference from the baseline value (p=0.46, Duncan test). The changes in the nasal average and temporal average RNFLT were not statistically significant. No correlation was found between the change in the SLP measured thickness values and central corneal thickness at baseline and its change after surgery, nor with the change in cylindrical correction due to LASIK, or the length of the suction time during surgery (p>0.05 for all correlations).

Conclusion: The SLP technique is sensitive to the corneal optical properties, and RNFLT as measured with SLP shows changes after LASIK. Most of these changes, however, diminish with time after surgery, and the values tend to return to the preoperative results during the first 3 months of corneal healing following uncomplicated LASIK. It appears that in uncomplicated cases the transient RNFLT changes are artefacts and do not imply pathological thickness alterations due to LASIK.

Keywords: cornea; LASIK; retinal nerve fibre analysis; scanning laser polarimetry

Abbreviations: BSCVA, best spectacle corrected visual acuity; BSS, balanced salt solution; LASIK, laser assisted in situ keratomileusis; RNFLT, retinal nerve fibre layer thickness; SLP, scanning laser polarimetry; UCVA, uncorrected visual acuity

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				M Centofanti, F Oddone, M Parravano, L Gualdi, M G Bucci, and G Manni Corneal birefringence changes after laser assisted in situ keratomileusis and their influence on retinal nerve fibre layer thickness measurement by means of scanning laser polarimetry Br. J. Ophthalmol., June 1, 2005; 89(6): 689 - 693. [Abstract] [Full Text] [PDF]

				G Hollo, A Katsanos, P Kothy, A Kerek, and I Suveges Influence of LASIK on scanning laser polarimetric measurement of the retinal nerve fibre layer with fixed angle and customised corneal polarisation compensation Br. J. Ophthalmol., October 1, 2003; 87(10): 1241 - 1246. [Abstract] [Full Text] [PDF]