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A randomised clinical trial comparing 2% econazole and 5% natamycin for the treatment of fungal keratitis

¹ Aravind Eye Care System, Madurai, India
² Lions Aravind Institute of Community Ophthalmology, Madurai, India

Correspondence to:
Correspondence to:
N Venkatesh Prajna, Cornea Service, Aravind Eye Care System, 1 Anna Nagar, Madurai-625020, India;
prajna{at}aravind.org

Aim: To compare 2% econazole and 5% natamycin in the management of fungal keratitis.

Methods: A randomised clinical trial was performed using 2% econazole or 5% natamycin as the two treatment arms on patients presenting with culture positive fungal keratitis to the cornea service at Aravind Eye Care System, Madurai, India.

Results: 116 patients were recruited, and 112 continued in the study. There were no significant differences between the two arms at baseline or for success (defined as a healed or healing ulcer) at final visit (p = 0.79).

Conclusions: 2% Econazole appears to be as effective as 5% natamycin for the management of fungal keratitis.

Keywords: fungal keratitis; randomised clinical trial; econazole; natamycin

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