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Fluorescein and indocyanine green angiography findings in Behçet’s disease

¹ Ankara University, School of Medicine, Department of Ophthalmology, Gazi Mustafa Kemal Bulvari 23/1, Kizilay 06440, Ankara, Turkey
² Gazi Mustafa Kemal Bulvari 23/1, Kizilay 06440, Ankara, Turkey

Correspondence to:
Correspondence to:
Professor Leyla S Atmaca
Gazi Mustafa Kemal Bulvari 23/1, Kizilay 06440, Ankara, Turkey; leylaatmaca{at}ttnet.net.tr

ABSTRACT
Aim: To evaluate and compare the fluorescein (FA) and indocyanine green angiographic (ICGA) findings, and to investigate the choroidal involvement in Behçet’s disease.

Methods: FA and ICGA were performed on 112 eyes of 62 patients with Behçet’s disease, between November 1993 and July 2002, using Topcon IMAGEnet Digital System. Patients were aged 16–50 years; 48 (77.4%) were male and 14 (22.6%) were female.

Results: FA showed dye leakage from retinal vessels in 57 (50.9%) eyes, cystoid macular oedema in 18 eyes (16.1%), optic disc oedema in four eyes (3.6%), disc neovascularisation in three eyes (2.7%), and retinal neovascularisation in two eyes (1.8%). ICGA showed hyperfluorescent lesions in 40 eyes (35.7%), hypofluorescent lesions in 17 eyes (15.2%), hyperfluorescent and hypofluorescent lesions in 12 (10.7%) eyes, ICG leakage from choroidal vessels in 11 eyes (9.8%), irregular filling of choriocapillaris in five eyes (4.5%), and choroidal filling defect in four eyes (3.6%). Hyperfluorescent and hypofluorescent lesions which were seen in 53 out of 69 eyes (76.8%) on ICGA, were not visible on FA. 55 eyes (49.1%) showed hyperfluorescence on the disc on both FA and ICGA, whereas 36 (32.1%) showed hyperfluorescence only on FA.

Conclusion: The hyperfluorescence and/or hypofluorescence, irregular filling of the choriocapillaris, choroidal filling defect, and ICG leakage from choroidal vessels seen only on ICGA may suggest choroidal involvement in Behçet’s disease.

Keywords: Behçet’s disease; fluorescein angiography; indocyanine green angiography; choroid