This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nolan, W P Articles by Johnson, G J Search for Related Content PubMed PubMed Citation Articles by Nolan, W P Articles by Johnson, G J

Screening for primary angle closure in Mongolia: a randomised controlled trial to determine whether screening and prophylactic treatment will reduce the incidence of primary angle closure glaucoma in an east Asian population

¹ Department of Epidemiology and International Eye Health, Institute of Ophthalmology, London, UK
² Department of Ophthalmology, Medical University Central Hospital, Ulaanbaatar, Mongolia

Correspondence to:
Correspondence to:
Winifred Nolan, Department of Epidemiology and International Eye Health, Institute of Ophthalmology, 11–43 Bath Street, London EC1V 9EL, UK;
winnienolan{at}hotmail.com

ABSTRACT
Aim: To describe the methods used and initial results of a prospective study designed to determine whether screening and prophylactic treatment will reduce the incidence of primary angle closure glaucoma (PACG) in Mongolia.

Methods: A total of 4725 individuals aged 50 years and above were recruited to the study and randomised to intervention or control groups. All subjects had non-mydriatic optic disc examination. The intervention arm had measurement of anterior chamber depth (ACD) by A-scan ultrasound and intraocular pressure (IOP) with Tonopen. Gonioscopy was performed on test positive cases (ACD <2.53 mm or IOP 24 mm Hg either eye). Those with occludable angles were offered laser iridotomy. Primary outcome will be incidence of PACG at 5 year follow up.

Results: Glaucoma was diagnosed in 128 (2.7%) subjects. Of the remaining 4597, 2293 were randomised to intervention. Intervention as allocated was received by 2280 (99.4%) individuals. 160 (23.4%) of 685 test positive cases had occludable angles, of which 156 were treated with iridotomy.

Conclusions: This trial is a further step in determining whether screening and prophylactic treatment for primary angle closure in east Asian populations will reduce the incidence of glaucoma.

Keywords: screening; primary angle closure glaucoma

This article has been cited by other articles:

				J L Y Yip, P J Foster, C E Gilbert, D Uranchimeg, J Bassanhuu, P S Lee, P T Khaw, G J Johnson, and W Nolan Incidence of occludable angles in a high-risk Mongolian population Br. J. Ophthalmol., January 1, 2008; 92(1): 30 - 33. [Abstract] [Full Text] [PDF]

				R J Casson, H S Newland, J Muecke, S McGovern, L M Abraham, W K Shein, D Selva, and T Aung Gonioscopy findings and prevalence of occludable angles in a Burmese population: the Meiktila Eye Study Br. J. Ophthalmol., July 1, 2007; 91(7): 856 - 859. [Abstract] [Full Text] [PDF]

				R R Bourne and P H Alsbirk Anterior chamber depth measurement by optical pachymetry: systematic difference using the Haag-Streit attachments Br. J. Ophthalmol., February 1, 2006; 90(2): 142 - 145. [Abstract] [Full Text] [PDF]

				T. Aung, W. P. Nolan, D. Machin, S. K. L. Seah, J. Baasanhu, P. T. Khaw, G. J. Johnson, and P. J. Foster Anterior Chamber Depth and the Risk of Primary Angle Closure in 2 East Asian Populations Arch Ophthalmol, April 1, 2005; 123(4): 527 - 532. [Abstract] [Full Text] [PDF]