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Influence of factor V Leiden on the development of neovascularisation secondary to central retinal vein occlusion

¹ Department of Ophthalmology, Lund University Hospital, Sweden
² Department of Clinical Chemistry, Malmö University Hospital, 211 85 Malmö, Sweden

Correspondence to:
Correspondence to:
Charlotte Hvarfner, Department of Ophthalmology, Lund University Hospital, 211 85 Lund, Sweden;
charlotte.hvarfner{at}oft.lu.se

Aims: To investigate if the presence of factor V Leiden has an influence on the prognosis in central retinal vein occlusion (CRVO).

Methods: 166 patients with CRVO were studied retrospectively. They were tested for factor V Leiden using DNA analysis. The presence of the mutation was studied in correlation with the development of neovascular complications 1 year after the thrombotic event.

Results: 56 of 166 patients (34%) developed neovascular complications after 1 year. In the patients who had the studied mutation 11 of 20 (55%) had developed neovascular complications after 1 year, compared to 45 of 146 patients (31%) in the group without factor V Leiden (p=0.04).

Conclusion: The presence of factor V Leiden seems to enhance the risk of developing neovascular complications in CRVO.

Keywords: central retinal vein occlusion; factor V Leiden; neovascular complications