This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Oster, S F Articles by Sretavan, D W Search for Related Content PubMed PubMed Citation Articles by Oster, S F Articles by Sretavan, D W

Connecting the eye to the brain: the molecular basis of ganglion cell axon guidance

Departments of Ophthalmology and Physiology, Medical Scientist Training Program, Biomedical Sciences Program, Neuroscience Program, University of California San Francisco, San Francisco, CA, USA

Correspondence to:
Correspondence to:
David W Sretavan, MD, PhD, Department of Ophthalmology, K107, Box 0730, University of California San Francisco, 10 Kirkham Street, San Francisco, CA 94143, USA;
dws{at}itsa.ucsf.edu

In the past several years, a great deal has been learnt about the molecular basis through which specific neural pathways in the visual system are established during embryonic development. This review provides a framework for understanding the principles of retinal ganglion cell axon guidance, and introduces some of the families of axon guidance molecules involved. In addition, the potential relevance of retinal axon guidance to human visual developmental disorders, and to retinal axon regeneration, is discussed.

Keywords: eye; brain; molecular basis; ganglion cell axon guidance

This article has been cited by other articles:

				P. Lempert Occlusion studies are ambiguous BMJ, October 27, 2007; 335(7625): 842 - 842. [Full Text] [PDF]

				L.-C. Huang, P. R. Thorne, G. D. Housley, and J. M. Montgomery Spatiotemporal definition of neurite outgrowth, refinement and retraction in the developing mouse cochlea Development, August 15, 2007; 134(16): 2925 - 2933. [Abstract] [Full Text] [PDF]

				T. Harada, C. Harada, and L. F. Parada Molecular regulation of visual system development: more than meets the eye Genes & Dev., February 15, 2007; 21(4): 367 - 378. [Abstract] [Full Text] [PDF]

				S. J. Butler and G. Tear Getting axons onto the right path: the role of transcription factors in axon guidance Development, February 1, 2007; 134(3): 439 - 448. [Abstract] [Full Text] [PDF]

				P. Lempert Contradictions in the amblyopia treatment studies. Arch Ophthalmol, February 1, 2006; 124(2): 285 - 285. [Full Text] [PDF]

				F. de Winter, Q. Cui, N. Symons, J. Verhaagen, and A. R. Harvey Expression of Class-3 Semaphorins and Their Receptors in the Neonatal and Adult Rat Retina Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4554 - 4562. [Abstract] [Full Text] [PDF]

				P. Lempert An Argument Against Axial Length-Disc Area Ratio as the Cause of Esotropic Amblyopia--Reply Arch Ophthalmol, November 1, 2004; 122(11): 1732 - 1733. [Full Text] [PDF]

				J. Zhang, Z. Jin, and Z.-Z. Bao Disruption of gradient expression of Zic3 resulted in abnormal intra-retinal axon projection Development, April 1, 2004; 131(7): 1553 - 1562. [Abstract] [Full Text] [PDF]