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Is granuloma annulare related to intermediate uveitis with retinal vasculitis?

¹ Department of Ophthalmology, FC Donders Institute, University Hospital Utrecht, Netherlands
² Department of Pathology, University Hospital Utrecht, Netherlands
³ Department of Dermatology, University Hospital Utrecht, Netherlands

Correspondence to:
Correspondence to:
Bram van Kooij, FC Donders Institute, Department of Ophthalmology, University Hospital Utrecht, PO Box 85500, 3508 GA Utrecht, Netherlands;
b.vankooij{at}oogh.azu.nl

Aim: To report on eight patients with severe idiopathic intermediate uveitis (IU) and granuloma annulare (GA), a self limiting cutaneous condition of unknown aetiology.

Methods: Retrospective case series. Clinical ophthalmic and dermatological data were studied and fluorescein angiography and skin biopsies were reviewed.

Results: All patients with idiopathic IU had similar ocular features (eight with vitritis, seven with retinal vasculitis) and developed complications such as cystoid macular oedema (n=5), cataract (n=4), and glaucoma (n=3). Systemic diseases were not found, but a localised type of GA was observed in all.

Conclusion: Seven out of eight patients with IU and GA developed severe retinal vasculitis. Further studies are needed for a better understanding of this association, a common pathogenesis, and its eventual clinical consequences.

Keywords: intermediate uveitis; granuloma annulare

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