This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kim, J H Articles by Hwang, J-M Search for Related Content PubMed PubMed Citation Articles by Kim, J H Articles by Hwang, J-M Topic Collections Related Article

Use of polyurethane with sustained release dexamethasone in delayed adjustable strabismus surgery

¹ Department of Ophthalmology, College of Medicine Seoul National University, Seoul National University Bundang Hospital, Seongnam, Korea
² Biomedical Research Center, Korea Institute of Science and Technology, Seoul, Korea

Correspondence to:
Correspondence to:
Jeong-Min Hwang MD
Department of Ophthalmology, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-ku, Seongnam, Gyeonggi-do 463-707, Korea; hjm{at}snu.ac.kr

Aim: To determine the effect of polyurethane film with sustained release dexamethasone (SRD) in delayed adjustable strabismus surgery.

Methods: A prospective, masked observer, controlled study was performed in rabbits. Thirty four rabbit eyes were divided into three groups. After recession of the superior rectus muscle (SRM), polyurethane film with or without SRD, or balanced salt solution was applied beneath and over SRM in the polyurethane-dexamethasone group (group P-D), polyurethane group (group P), and the control group (group C), respectively. Delayed adjustment was performed once on each SRM at 4 and 6 weeks postoperatively by a masked observer. The possible length to adjust and the necessary force required for the adjustment, as well as the degree of any adhesions, were also evaluated.

Results: In the control group, adjustment was impossible in all of the eyes at 4 and 6 weeks postoperatively. In group P-D, adjustment was possible in 11 out of 11 eyes (11/11) 4 weeks postoperatively and in 10/11 eyes 6 weeks postoperatively. In group P, adjustment was possible in 9/11 eyes 4 weeks postoperatively and in 10/12 eyes 6 weeks postoperatively.

Conclusions: Use of polyurethane film with and without SRD could delay adjustment in most eyes for up to 6 weeks postoperatively. Polyurethane is helpful for delaying adjustment in rabbit eyes until 6 weeks postoperatively without the need for frequent topical instillation of steroids.

Abbreviations: SRD, sustained release dexamethasone; SRM, superior rectus muscle

Keywords: polyurethane; dexamethasone; strabismus; surgery; rabbits

Related Article

BJO at a glance

Creig Hoyt
Br. J. Ophthalmol. 2004 88: 1357. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				M. J. Lee, S.-E. Jin, C.-K. Kim, H.-K. Choung, J. W. Jeoung, H. J. Kim, G. Choe, and J.-M. Hwang Slow-Releasing Tranilast in Polytetrafluoroethylene/Polylactide-co-glycolide Laminate Delays Adjustment after Strabismus Surgery in Rabbit Model Invest. Ophthalmol. Vis. Sci., February 1, 2007; 48(2): 699 - 704. [Abstract] [Full Text] [PDF]

				J.-P. Jee, H.-K. Choung, C.-K. Kim, and J.-M. Hwang Polytetrafluoroethylene/Polylactide-co-Glycolide Laminate Containing Dexamethasone Allows Delayed Adjustable Strabismus Surgery in a Rabbit Model. Invest. Ophthalmol. Vis. Sci., June 1, 2006; 47(6): 2485 - 2490. [Abstract] [Full Text] [PDF]