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Case selection in macular relocation surgery for age related macular degeneration

¹ St Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool, UK
² Experimental Ophthalmology Unit, Department of Medicine, University of Liverpool, UK

Correspondence to:
Correspondence to:
Mr David Wong
Consultant Ophthalmologist, St, Paul’s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK; shdwong{at}liverpool.ac.uk

ABSTRACT
Background: To date there has been no randomised controlled trial demonstrating the safety and efficacy of macular relocation surgery (MRS) for age related macular degeneration (AMD). Vision can be improved in some patients and made worse in others despite successful surgery or because of complications.

Purpose: To determine which patients would benefit from MRS.

Methods: Twenty nine patients with exudative AMD took part in a prospective, non-comparative, interventional study. Macular relocation surgery involved phacoemulsification, vitrectomy, 360° retinotomy, excision of choroidal neovascular membrane, and macular relocation using an infusion of 5-fluorouracil and low molecular weight heparin as adjuvant to prevent proliferative vitreoretinopathy. Patients underwent protocol refraction preoperatively and six-monthly postoperatively by designated optometrists. Preoperative fundus fluorescein angiograms were read by masked observers and the lesions were classified according to a set protocol. The main outcome measures were visual improvement, final vision of better than 20/400, reading speed, critical print size. Logistic and multiple stepwise linear regressions were used to identify independent factors which predicted the main outcomes.

Results: Preoperative visual acuity (20/120 or worse) and lesion type (predominantly classic or submacular haemorrhage) were significantly associated with visual improvement (coefficient of regression B = 26.8, p<0.001 and B = 14.9 with p = 0.045 respectively). There were no significant independent factors which predicted a final distance logMAR visual acuity of 1.3 (20/400) or any arbitrary definition of blindness.

Conclusions: The study showed that it was possible to select cases that were more likely to experience an improvement in vision following MRS.

Keywords: Age related macular degeneration; case selection; macular relocation surgery; prospective non-comparative interventional study

Abbreviations: AMD, age related macular degeneration; CNV, choroidal neovascularisation; FFA, fundus fluorescein angiography; LMWH, low molecular weight heparin; MRS, macular relocation surgery; PRCT, prospective randomised controlled trial

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