BJO

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Allegaert, K
Right arrow Articles by Devlieger, H
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Allegaert, K
Right arrow Articles by Devlieger, H
Topic Collections
Right arrowRelevant Article
British Journal of Ophthalmology 2004;88:239-242
© 2004 BMJ Publishing Group Ltd

EXTENDED REPORT

Threshold retinopathy at threshold of viability: the EpiBel study

K Allegaert1, K de Coen2, H Devlieger1 on behalf of the EpiBel Study group

1 University Hospital, Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
2 University Hospital, De Pintelaan, 185 9000 Ghent, Belgium

Correspondence to:
Correspondence to:
K Allegaert
MD, University Hospitals, Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium; karel.allegaert{at}uz.kuleuven.ac.be

Aim: To describe incidence, co-morbidity characteristics, and risk factors associated with threshold retinopathy of prematurity (ROP) in survivors with a gestational age (GA) of <=26 weeks at birth.

Methods: Retrospective analysis of perinatal data of all inborn survivors in all perinatal centres of Belgium in the period 1999–2000 (EpiBel cohort) believed to be between 22 and 26 weeks GA at time of delivery. Data on survivors who did and survivors who did not develop threshold ROP were compared ({chi}2, Mann-Whitney U) and logistic regression was performed.

Results: Of 303 admitted infants 175 (58%) were discharged alive. Incidence of major retinopathy (>=stage 3) and of threshold ROP was 25.5% and 19.8% in survivors. Associated central nervous abnormalities were documented in six (17%) and associated chronic lung disease in 19 (54%) threshold ROP infants. Threshold ROP without additional morbidity characteristics at discharge was documented in 14 (40%) infants. Besides often reported risk factors, renal insufficiency (creatinaemia>1.5 mg/dl) was a risk factor to develop threshold ROP (p<0.0015) ({chi}2). Days of respiratory support (OR 1.02; 95% CI 1.002 to 1.039), number of transfusions (OR 1.118; 95% CI 1.030 to 1.214), and renal insufficiency (OR 3.31; 95% CI 1.344 to 8.196) remained independent risk factors to develop threshold ROP in this cohort in a stepwise logistic regression model (MedCalc).

Conclusions: Incidence of threshold ROP is high at the limits of viability. Renal insufficiency is a risk factor to develop threshold ROP in this cohort.

Keywords: threshold retinopathy; low birthweight infants; renal insufficiency; morbidity


Relevant Article

The nine lives of retinopathy of prematurity
W V Good
Br. J. Ophthalmol. 2004 88: 160-161. [Extract] [Full Text] [PDF]



This article has been cited by other articles:


Home page
 PediatricsHome page
M. E. Msall
The retina as a window to the brain in vulnerable neonates.
Pediatrics, June 1, 2006; 117(6): 2287 - 2289.
[Full Text] [PDF]

Home page
 PediatricsHome page
Early Treatment for Retinopathy of Prematurity Coo
The Incidence and Course of Retinopathy of Prematurity: Findings From the Early Treatment for Retinopathy of Prematurity Study
Pediatrics, July 1, 2005; 116(1): 15 - 23.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
B. A. Darlow, J. L. Hutchinson, D. J. Henderson-Smart, D. A. Donoghue, J. M. Simpson, N. J. Evans, and on behalf of the Australian and New Zealand Neonat
Prenatal Risk Factors for Severe Retinopathy of Prematurity Among Very Preterm Infants of the Australian and New Zealand Neonatal Network
Pediatrics, April 1, 2005; 115(4): 990 - 996.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
D Clark
Threshold ROP
Br. J. Ophthalmol., December 1, 2004; 88(12): 1484 - 1484.
[Full Text] [PDF]

Home page
 PediatricsHome page
P. Vanhaesebrouck, K. Allegaert, J. Bottu, C. Debauche, H. Devlieger, M. Docx, A. Francois, D. Haumont, J. Lombet, J. Rigo, et al.
The EPIBEL Study: Outcomes to Discharge From Hospital for Extremely Preterm Infants in Belgium
Pediatrics, September 1, 2004; 114(3): 663 - 675.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2004 by the BMJ Publishing Group Ltd.