This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Luu, C D Articles by Tan, D Search for Related Content PubMed PubMed Citation Articles by Luu, C D Articles by Tan, D Topic Collections Relevant Article

Multifocal electroretinogram in children on atropine treatment for myopia

¹ Singapore Eye Research Institute, Singapore
² Singapore National Eye Centre, Singapore

Correspondence to:
Correspondence to:
Dr Chi D Luu
Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751; seri_chiluu{at}snec.com.sg

ABSTRACT
Aim: To assess retinal function by multifocal electroretinogram (mfERG) in children on atropine eye drops for the treatment of myopia.

Methods: mfERGs were recorded in children receiving atropine eye drops (n = 48) once daily for 2 years and in those receiving placebo eye drops (n = 57) for a similar time. All recordings were performed between the second and third month of cessation of atropine/placebo treatment by a masked investigator. The amplitude and implicit time of the first order kernel (k1) and first slice of the second order kernel (k21) of mfERG responses were used to study the outer and inner retinal function, respectively.

Results: There was no significant reduction in k1 response amplitudes of the atropine group compared to that of the placebo group (N1, p = 0.181; P1, p = 0.150). No significant difference in the k1 response implicit times between the groups was found (N1, p = 0.767; P1, p = 0.849). The differences in the k21 amplitudes and implicit times between the groups were not statistically significant (k21 amplitude, p = 0.058; k21 implicit time, p = 0.156).

Conclusions: Daily atropine usage over 2 years for the treatment of myopia has no significant effect on retinal function as demonstrated by recordings of mfERG.

Abbreviations: ATOM study, Atropine in the Treatment of Myopia study; ISCEV, International Society for Clinical Electrophysiology of Vision; mfERG, multifocal electroretinogram

Keywords: retina; electroretinogram; multifocal electroretinogram; myopia; atropine

Relevant Article

BJO at a glance

Creig Hoyt
Br. J. Ophthalmol. 2005 89: 127. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				S. Liu, J. Li, D. T. H. Tan, and R. W. Beuerman Expression and Function of Muscarinic Receptor Subtypes on Human Cornea and Conjunctiva Invest. Ophthalmol. Vis. Sci., July 1, 2007; 48(7): 2987 - 2996. [Abstract] [Full Text] [PDF]