This Article Full Text Full Text (PDF) Submit a response Read responses to this article Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Klein, B E K Articles by Knudtson, M D Search for Related Content PubMed PubMed Citation Articles by Klein, B E K Articles by Knudtson, M D

Intraocular pressure and systemic blood pressure: longitudinal perspective: the Beaver Dam Eye Study

Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI, USA

Correspondence to:
Correspondence to:
Barbara E K Klein MD MPH
Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 610 North Walnut Street, 4th Floor WARF, Madison, WI 53726-2336, USA; kleinb{at}epi.ophth.wisc.edu

ABSTRACT
Aim: To investigate the relation between change in systemic blood pressures and change in intraocular pressure.

Methods: This was a population based study of people 43–86 years old living in Beaver Dam, Wisconsin. Measurements at baseline (1988–90) and 5 year follow up of systemic blood pressures, intraocular pressures, and history of use of blood pressure medications.

Results: Intraocular pressures were significantly correlated with systolic and diastolic blood pressures at both baseline and follow up. There were significant direct correlations between changes in systemic blood pressures and changes in intraocular pressure. There was a 0.21 (95% CI: 0.16 to 0.27) mm Hg increase in IOP for a 10 mm Hg increase in systolic and 0.43 (0.35 to 0.52) mm Hg increase in IOP for a 10 mm Hg increase in diastolic blood pressure. Further adjustment for diabetes and medication use did not alter these associations. Decreased systolic or diastolic blood pressures of more than 10 mm Hg over 5 years were significantly associated with decreased IOP.

Conclusions: Reduced systemic blood pressure is associated with reduced intraocular pressure. This finding should be evaluated in other studies, especially with respect to the possibility of resultant decreased risk of open angle glaucoma.

Abbreviations: DBP, diastolic blood pressure; IOP, intraocular pressure; SBP, systolic blood pressure

Keywords: intraocular pressure; systemic blood pressure; Beaver Dam Eye Study

This article has been cited by other articles:

				K Kawase, A Tomidokoro, M Araie, A Iwase, T Yamamoto, Tajimi Study Group, and Japan Glaucoma Society Ocular and systemic factors related to intraocular pressure in Japanese adults: the Tajimi study Br. J. Ophthalmol., September 1, 2008; 92(9): 1175 - 1179. [Abstract] [Full Text] [PDF]

				J. E. A. Somner, D. S. Morris, K. M. Scott, I. J. C. MacCormick, P. Aspinall, and B. Dhillon What Happens to Intraocular Pressure at High Altitude? Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1622 - 1626. [Abstract] [Full Text] [PDF]

				J. Choi, K. H. Kim, J. Jeong, H.-s. Cho, C. H. Lee, and M. S. Kook Circadian Fluctuation of Mean Ocular Perfusion Pressure Is a Consistent Risk Factor for Normal-Tension Glaucoma Invest. Ophthalmol. Vis. Sci., January 1, 2007; 48(1): 104 - 111. [Abstract] [Full Text] [PDF]

				P. Duggal, A. P. Klein, K. E. Lee, R. Klein, B. E. K. Klein, and J. E. Bailey-Wilson Identification of Novel Genetic Loci for Intraocular Pressure: A Genomewide Scan of the Beaver Dam Eye Study Arch Ophthalmol, January 1, 2007; 125(1): 74 - 79. [Abstract] [Full Text] [PDF]

				S.-Y. Wu, B. Nemesure, A. Hennis, M. C. Leske, and for the Barbados Eye Studies Group Nine-year changes in intraocular pressure: the barbados eye studies. Arch Ophthalmol, November 1, 2006; 124(11): 1631 - 1636. [Abstract] [Full Text] [PDF]

				V. K. Gupta Closure of ASD: what aggravates the migrainous diathesis? Eur. Heart J., July 2, 2006; 27(14): 1756 - 1757. [Full Text] [PDF]

				N. Witt, T. Y. Wong, A. D. Hughes, N. Chaturvedi, B. E. Klein, R. Evans, M. McNamara, S. A. M. Thom, and R. Klein Abnormalities of Retinal Microvascular Structure and Risk of Mortality From Ischemic Heart Disease and Stroke Hypertension, May 1, 2006; 47(5): 975 - 981. [Abstract] [Full Text] [PDF]

				L. F. Drager, P. A. Lotufo, I. M. Bensenor, and V. K. Gupta Letter Regarding Article by Law et al, "Headaches and the Treatment of Blood Pressure: Results From a Meta-Analysis of 94 Randomized Placebo-Controlled Trials With 24 000 Participants" * Disclosures Circulation, February 21, 2006; 113(7): e164 - e165. [Full Text] [PDF]

eLetters: