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A pilot study on the use of a perfluorohexyloctane/silicone oil solution as a heavier than water internal tamponade agent

¹ St Paul’s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
² The Rotterdam Eye Hospital, Schiedamsevest 180, 3011 BH, Rotterdam, Netherlands

Correspondence to:
Correspondence to:
Mr David Wong
St Paul’s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK; shdwong{at}liv.ac.uk

ABSTRACT
Aims: To report a prospective two centred non-comparative interventional pilot study of a solution of perfluorohexyloctane and silicone oil (Densiron-68) as a heavier than water internal tamponade.

Methods: 42 consecutive patients were recruited. The indications include proliferative vitreoretinopathy, retinal detachments arising from inferior retinal breaks, and inability to posture.

Results: The success rate with one operation using Densiron was 81% and with further surgery 93%. At the end of the study all tamponade agents were removed in 90% of patients. Visual acuity improved from mean logMAR of 1.41 (SD 0.64) to 0.94 (SD 0.57), p = 0.001. There was little evidence of dispersion and excessive inflammation.

Conclusion: This new tamponade agent is being compared to conventional silicone oil in a prospective international randomised trial.

Abbreviations: ERM, epiretinal membranes; PFCL, perfluorocarbon liquids; PPV, pars plana vitrectomy; PVR, proliferative vitreoretinopathy; RD, retinal detachments; SiO, silicone oil

Keywords: perfluorohexyloctane; silicone oil; proliferative vitreoretinopathy; retinal detachment

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"Heavy oil" for intraocular tamponade in retinal detachment surgery

R B Bhisitkul and V H Gonzalez
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