This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Funnell, C L Articles by Anand, N Search for Related Content PubMed PubMed Citation Articles by Funnell, C L Articles by Anand, N Topic Collections Relevant Article

Combined cataract and glaucoma surgery with mitomycin C: phacoemulsification-trabeculectomy compared to phacoemulsification-deep sclerectomy

¹ West Yorkshire Rotation, Clarendon Wing, Leeds General Infirmary, Leeds, UK
² Department of Ophthalmology, Calderdale and Huddersfield NHS Trust, Huddersfield Royal Infirmary, Huddersfield HD3 3EA, UK

Correspondence to:
Correspondence to:
Mr Nitin Anand
Department of Ophthalmology, Huddersfield Royal Infirmary, Lindley, Huddersfield HD3 3EA, UK; nitin.anand{at}lycos.co.uk

Aims: To compare outcomes of phacoemulsification combined with trabeculectomy (PT) or deep sclerectomy (PDS) with intraoperative mitomycin C (MMC) application.

Methods: Non-randomised, consecutive, retrospective comparative study. 97 eyes of 97 patients (59 PDS, 38 PT) undergoing combined surgery with intraoperative MMC (0.1–0.4 mg/ml for 1–3 minutes) were identified for inclusion in the study.

Results: The probability of maintaining intraocular pressure (IOP) below 19 mm Hg and 15 mm Hg, with a 30% drop from preoperative IOP and without additional medication, 1 year after surgery were 77.6% (95% CI: 67 to 90) and 71.5% (60 to 85) for the PDS group and 89.5% (80 to 99) and 89.5 (80 to 99) for the PT group, respectively, and these differences were not statistically significant (p>0.05, log rank test). After excluding ocular co-morbidity no differences were observed in the improvement of visual acuity between the two groups. There were no major differences in the complication rates except that delayed bleb leaks were seen in seven eyes (18.4%) of the PT group (p = 0.004).

Conclusion: In this study, no statistically significant difference was found in the IOP and visual outcomes between PDS and PT. A significantly higher frequency of late bleb leaks after PT was observed.

Abbreviations: 5-FU, 5-fluorouracil; IOP, intraocular pressure; MMC, mitomycin C; NPGS, non-penetrating glaucoma surgery; PT, phacoemulsification combined with trabeculectomy; PDS, phacoemulsification combined with deep sclerectomy; PVCT, phacoemulsification combined with viscocanalostomy; TDM, trabeculo-Descemet’s membrane

Keywords: cataract surgery; glaucoma surgery; mitomycin C; phacoemulsification; trabeculectomy; deep sclerectomy

Relevant Article

BJO at a glance

Creig Hoyt
Br. J. Ophthalmol. 2005 89: 647. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				N Anand, S Arora, and M Clowes Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks Br. J. Ophthalmol., February 1, 2006; 90(2): 175 - 180. [Abstract] [Full Text] [PDF]