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Outcomes in persistent hyperplastic primary vitreous

¹ Department of Ophthalmology, The University of Sydney, New South Wales, Australia
² Department of Radiology, The Children’s Hospital, Westmead, Sydney, Australia

Correspondence to:
Correspondence to:
Dr Adrian Robert Hunt
Sydney Eye Hospital, 8 Macquarie Street, Sydney, Australia 2000; hunt_adrian{at}bigpond.com

Aims: To report outcomes in cases of persistent hyperplastic primary vitreous (PHPV) and examine factors predictive of visual acuity in patients selected for surgery.

Methods: Retrospective case series of 55 eyes in 50 patients presenting between 1990 and 2001 at the Children’s Hospital, Westmead. 33 eyes underwent surgery aimed at visual rehabilitation.

Results: In surgical patients, median age at surgery was 77 days, and median age at final follow up was 28 months. Six (18%) achieved a visual acuity at final follow up of 6/60 or better and eight (24%) achieved acuity of less than 6/60 to counting finger vision inclusive. Those undergoing surgery before 77 days were approximately 13 times more likely to obtain a visual acuity of counting fingers or better than those operated later (p = 0.01). Neither posterior segment PHPV nor post-surgical glaucoma was a significant predictor of outcome in this selected group.

Conclusion: Early surgery aimed at rehabilitation markedly improves the likelihood of useful visual outcome in selected eyes with PHPV.

Abbreviations: CT, computed tomography; MRI, magnetic resonance imaging; PFV, persistent fetal vasculature; PHPV, persistent hyperplastic primary vitreous; VEP, visual evoked potentials

Keywords: hyperplastic primary vitreous; children

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